RARE DISEASE
Benign tumor of fallopian tubes
Benign tumor of fallopian tubes
Benign tumor of fallopian tubes
Drug discovery
0
drugs
With orphan designations
Overview
Benign fallopian tube tumors are rare non-metastasizing neoplasms arising from tubal epithelium or stromal tissue, including serous adenofibromas, papillomas, and mature teratomas [1][5][14]. Most cases are asymptomatic, though some present with tubal obstruction, pelvic pain, or incidental findings during surgery for unrelated conditions [1][5][14]. Diagnosis often requires histopathological confirmation after imaging detects adnexal masses.
Categories: rare gynecological and obstetric diseases, rare neoplastic diseases
Research Papers
55 drug discovery papers about Benign tumor of fallopian tubes, with 2 first-in-class emerging drug candidates forecasted to outperform the average preclinical success rate. Recent publications:
55 drug discovery papers about Benign tumor of fallopian tubes, with 2 first-in-class emerging drug candidates forecasted to outperform the average preclinical success rate. Recent publications:
2025-11-19 | Age, lifestyle, and disease affect ciliary transport in the human fallopian tube.
The synchronized beating of ciliated cells within the human fallopian tube is crucial for the transport of the oocyte and the early embryo. To date, the precise effects of age, lifestyle, and disease on ciliary beating in the human fallopian tube are still unknown. Therefore, we set out to evaluate the effects of cycle stage, age, BMI, smoking, and alcohol, as well as the impact of ovarian cysts, uterine fibroids (myomas), cervical cancer, and endometrial cancer on human tubal ciliary beat frequency (CBF). Samples were obtained from control patients undergoing risk reduction surgery as well as from patients with ovarian cysts, benign myomas, as well as from patients with cervical cancer and endometrial cancer. Tubal samples were obtained during hysterectomy with salpingo-oophorectomy and examined using quantitative digital live cell imaging under near in vivo conditions and in real-time. Our results showed that tubal CBF was independent of cycle stage and anatomical location in the oviduct. There was a significant relationship between patient age and CBF (< 45 years Spearman's rho=-0.708, p = < 0.001 and > 45 years Spearman's rho=-0.752, p = < 0.001). Smoking caused a significant increase in CBF (generalised linear model, p = 0.025), whereas regular alcohol consumption had no effect. Increased BMI was associated with significantly decreased CBF (Spearman's rho=-0.543, p = 0.024). CBF was also significantly decreased in cycling patients affected by ovarian cysts (generalised linear model for repeated measurements, p = 0.004), in patients with uterine myomas (generalised linear model, p = 0.027), as well as in patients with cervical cancer (cycling patients, generalised linear model, p = 0.002) and endometrial cancer (menopausal patients, generalised linear model, p = 0.003). Overall, our results show that tubal ciliary function is impaired by obesity and smoking, as well as by benign myomas and malignant gynaecological cancer. Altered CBF impairs proper embryo transport speed, decreasing the chance of successful pregnancy. Thus, modulating early embryo transport might be a valuable tool for optimizing the success rates of assisted reproductive technologies (ART) both in infertile healthy patients as well as in young cervical cancer patients.
2025-07-10 | Bilateral Borderline Serous Tumor of Fallopian Tube in a Child With Klippel-Trenaunay Syndrome: An Exceptionally Rare Combination.
Klippel-Trenaunay syndrome (KTS) is a rare overgrowth disorder characterized by capillary malformations, vascular anomalies, and limb length discrepancies. It is a congenital, mostly sporadic disorder with unknown pathogenesis, though recent studies have shown an association with somatic mosaic-activating mutations in the PIK3CA gene. The prognosis is variable, depending on the clinical presentation. Visceral involvement in KTS is rare, usually in the form of hemangiomas or venous malformations. Varied neoplastic pathologies have been reported in KTS; however, unlike other overgrowth syndromes, no clear association between KTS and malignancy has so far been elucidated. We report herein an account of a 2-yr-old female child with KTS who presented with abdominal distention and was diagnosed to have a serous borderline tumor (SBT) of bilateral fallopian tubes. Fallopian tube SBT is exceptionally rare and, to the best of our knowledge, has only been reported once previously in a premenarchal patient, who, incidentally, also had KTS. Bilateral fallopian tube involvement in a pediatric SBT has not been described hitherto.
2025-02-09 | Oral contraceptive use is associated with a reduction in the physical size of fallopian tube p53 signatures.
Oral contraceptives reduce ovarian cancer risk, but the mechanism of risk reduction is not understood. We examined whether oral contraceptive pill (OCP) use influences p53 signatures, which are putative early fallopian tube precursors for high-grade serous ovarian carcinomas. For this retrospective cohort (n = 250) of subjects aged over 50 years who had fallopian tubes removed at the time of a benign gynecologic procedure, we used health records to identify 72 patients who used OCPs for at least 5 years and 178 subjects with no history of OCP use. Immunohistochemistry for p53 was performed on all fallopian tube sections, with 8 individuals removed for lack of identifiable tissue. p53 Signatures were identified and stratified based on size. Logistic regressions were run to estimate the association between OCP use and p53 lesion and lesion size. There was no difference in the occurrence of p53 lesions with 20 of 70 of OCP users (28.6%) and 57 of 172 of those with no history of OCP use (33.1%). Subjects who used OCPs were more likely to have a small lesion (OR 1.98, 95% CI 1.03 to 3.83) and had decreased risk of having a medium/large lesion (OR 0.38, 95% CI 0.18 to 0.79). A total of 2 serous tubal intraepithelial lesions and 2 serous tubal intraepithelial carcinomas were identified in OCP-naive patients, whereas none were found in those with a history of OCP use. OCP exposure was associated with a shift toward smaller p53 lesion size but was not found to be associated with a difference in the number of p53 lesions between OCP-exposed and unexposed patients. Future research should examine whether OCP use reduces proliferation and clonal expansion of p53 signature lesions toward higher risk precursors and, eventually, cancer. There were no serous tubal intraepithelial lesions and serous tubal intraepithelial carcinomas in patients with OCP exposure.
2025-11-19 | Age, lifestyle, and disease affect ciliary transport in the human fallopian tube.
The synchronized beating of ciliated cells within the human fallopian tube is crucial for the transport of the oocyte and the early embryo. To date, the precise effects of age, lifestyle, and disease on ciliary beating in the human fallopian tube are still unknown. Therefore, we set out to evaluate the effects of cycle stage, age, BMI, smoking, and alcohol, as well as the impact of ovarian cysts, uterine fibroids (myomas), cervical cancer, and endometrial cancer on human tubal ciliary beat frequency (CBF). Samples were obtained from control patients undergoing risk reduction surgery as well as from patients with ovarian cysts, benign myomas, as well as from patients with cervical cancer and endometrial cancer. Tubal samples were obtained during hysterectomy with salpingo-oophorectomy and examined using quantitative digital live cell imaging under near in vivo conditions and in real-time. Our results showed that tubal CBF was independent of cycle stage and anatomical location in the oviduct. There was a significant relationship between patient age and CBF (< 45 years Spearman's rho=-0.708, p = < 0.001 and > 45 years Spearman's rho=-0.752, p = < 0.001). Smoking caused a significant increase in CBF (generalised linear model, p = 0.025), whereas regular alcohol consumption had no effect. Increased BMI was associated with significantly decreased CBF (Spearman's rho=-0.543, p = 0.024). CBF was also significantly decreased in cycling patients affected by ovarian cysts (generalised linear model for repeated measurements, p = 0.004), in patients with uterine myomas (generalised linear model, p = 0.027), as well as in patients with cervical cancer (cycling patients, generalised linear model, p = 0.002) and endometrial cancer (menopausal patients, generalised linear model, p = 0.003). Overall, our results show that tubal ciliary function is impaired by obesity and smoking, as well as by benign myomas and malignant gynaecological cancer. Altered CBF impairs proper embryo transport speed, decreasing the chance of successful pregnancy. Thus, modulating early embryo transport might be a valuable tool for optimizing the success rates of assisted reproductive technologies (ART) both in infertile healthy patients as well as in young cervical cancer patients.
2025-07-10 | Bilateral Borderline Serous Tumor of Fallopian Tube in a Child With Klippel-Trenaunay Syndrome: An Exceptionally Rare Combination.
Klippel-Trenaunay syndrome (KTS) is a rare overgrowth disorder characterized by capillary malformations, vascular anomalies, and limb length discrepancies. It is a congenital, mostly sporadic disorder with unknown pathogenesis, though recent studies have shown an association with somatic mosaic-activating mutations in the PIK3CA gene. The prognosis is variable, depending on the clinical presentation. Visceral involvement in KTS is rare, usually in the form of hemangiomas or venous malformations. Varied neoplastic pathologies have been reported in KTS; however, unlike other overgrowth syndromes, no clear association between KTS and malignancy has so far been elucidated. We report herein an account of a 2-yr-old female child with KTS who presented with abdominal distention and was diagnosed to have a serous borderline tumor (SBT) of bilateral fallopian tubes. Fallopian tube SBT is exceptionally rare and, to the best of our knowledge, has only been reported once previously in a premenarchal patient, who, incidentally, also had KTS. Bilateral fallopian tube involvement in a pediatric SBT has not been described hitherto.
2025-02-09 | Oral contraceptive use is associated with a reduction in the physical size of fallopian tube p53 signatures.
Oral contraceptives reduce ovarian cancer risk, but the mechanism of risk reduction is not understood. We examined whether oral contraceptive pill (OCP) use influences p53 signatures, which are putative early fallopian tube precursors for high-grade serous ovarian carcinomas. For this retrospective cohort (n = 250) of subjects aged over 50 years who had fallopian tubes removed at the time of a benign gynecologic procedure, we used health records to identify 72 patients who used OCPs for at least 5 years and 178 subjects with no history of OCP use. Immunohistochemistry for p53 was performed on all fallopian tube sections, with 8 individuals removed for lack of identifiable tissue. p53 Signatures were identified and stratified based on size. Logistic regressions were run to estimate the association between OCP use and p53 lesion and lesion size. There was no difference in the occurrence of p53 lesions with 20 of 70 of OCP users (28.6%) and 57 of 172 of those with no history of OCP use (33.1%). Subjects who used OCPs were more likely to have a small lesion (OR 1.98, 95% CI 1.03 to 3.83) and had decreased risk of having a medium/large lesion (OR 0.38, 95% CI 0.18 to 0.79). A total of 2 serous tubal intraepithelial lesions and 2 serous tubal intraepithelial carcinomas were identified in OCP-naive patients, whereas none were found in those with a history of OCP use. OCP exposure was associated with a shift toward smaller p53 lesion size but was not found to be associated with a difference in the number of p53 lesions between OCP-exposed and unexposed patients. Future research should examine whether OCP use reduces proliferation and clonal expansion of p53 signature lesions toward higher risk precursors and, eventually, cancer. There were no serous tubal intraepithelial lesions and serous tubal intraepithelial carcinomas in patients with OCP exposure.
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